An archival research resource dedicated to spinal cord injury (SCI), the Sygen clinical trial, and peripheral nerve regeneration research. Originally established to share clinical and research information among patients, clinicians and advocates.
This site collects materials from the late 1990s and 2000s on spinal cord injury research, including the landmark Sygen multicentre trial of monosialotetrahexosylganglioside (GM1) for acute spinal cord injury. The pages also preserve patient discussion archives, peripheral nerve regeneration notes and links to the broader SCI research community.
The Sygen trial examined whether GM1 ganglioside, administered within 72 hours of injury, could improve neurological recovery in patients with severe traumatic spinal cord injury. The trial enrolled 760 patients across 28 centres. See the Sygen archive for protocol notes and outcome summaries.
Peripheral nerve research has long informed central nervous system repair strategies. Schwann cells, neurotrophic factors and conditioning lesions are recurring themes in attempts to bridge SCI lesions. See the peripheral nerve notes for archived discussion.
The spine research page archives discussion on dorsal column stimulation, decompression timing, methylprednisolone (NASCIS protocols), and the long debate over hypothermia in acute injury management. Patient-relevant material focuses on what was, at the time of writing, established standard of care versus experimental research.
The patient discussion area preserved conversations among SCI patients, family members, clinicians and researchers. Topics ranged from autonomic dysreflexia management to bowel and bladder programmes, pressure sore prevention, transfer techniques, and ongoing experimental therapies. The chat archive preserves selected threads.
The FAQ covers commonly raised topics on SCI prognosis, the difference between complete and incomplete injury, ASIA classification, and rehabilitation milestones. The information here is archival and was current at time of writing; clinical advice must come from a treating physician.
Archival content. This site does not provide medical advice. Patients should consult their clinical team. © Cure Paralysis Resource.